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2 How Does Antibiotic Use Lead to C Difficile Infections

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Review

. 2018 Jun;18(3):237-241.

doi: 10.7861/clinmedicine.18-3-237.

Clostridium difficile infection and antibiotic-associated diarrhoea

Affiliations

  • PMID: 29858434
  • PMCID: PMC6334067
  • DOI: 10.7861/clinmedicine.18-3-237

Free PMC article

Review

Clostridium difficile infection and antibiotic-associated diarrhoea

Benjamin H Mullish  et al. Clin Med (Lond). 2018 Jun .

Free PMC article

Abstract

Antibiotic-associated diarrhoea is among the most common adverse events related to antibiotic use. Most cases are mild, but Clostridium difficile infection causes a spectrum of disease, ranging from occasional diarrhoea to colitis, toxic megacolon, and potentially death. Recent developments in our understanding of the biology of the gut microbiota have provided new insights into the pathogenesis of these conditions, and have revealed a role for manipulation of the gut microbiota as a novel therapeutic approach. This review will give an overview of the assessment of these conditions, before focusing on the rapidly developing area of their treatment.

Keywords: Clostridium difficile; antibiotics; diarrhoea; faecal microbiota transplant; microbiota.

Figures

Fig 1.
Fig 1.

Pseudomembranous colitis.

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2 How Does Antibiotic Use Lead to C Difficile Infections

Source: https://pubmed.ncbi.nlm.nih.gov/29858434/

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